Anti TPO Test Price, Purpose, Results and Range [2024]
Anti TPO antibodies test is a common test for the diagnosis of thyroid disorders. In autoimmune diseases of thyroid glands, the patient’s immune system makes antibodies that mistakenly attack normal tissue of thyroid glands. The Anti-TPO antibodies attacking the thyroid gland cause swelling, rarely tenderness and reduced normal functioning of the thyroid. Anti TPO test prices range from Rs 600 to Rs 1300 in India.
Anti TPO test detects the autoimmune disorders of thyroid glands such as Graves’ disease or Hashimoto’s disease. TPO (Thyroid peroxidase) enzyme is crucial in producing thyroid hormones T3 and T4. These hormones regulate growth and development in the human body. Thus, high Anti TPO antibodies in the blood may indicate a thyroid disorder.
Anti TPO test details in brief.
| Also known as | Anti TPO Antibodies test, Thyroid peroxidase antibody test, TPO antibody test, Antithyroid antibodies test, AMA Test |
| Purpose | Diagnosis of Hashimoto’s disease or Graves’ disease, hypothyroidism |
| Preparation | Avoid multivitamins or dietary supplements containing biotin (vitamin B7). |
| Fasting required | No fasting is required. |
| Reporting time | 8 to 24 hours |
| Cost | Rs 600 to Rs 1300 |
Anti TPO test price
Anti-TPO test price depends on diagnostic centres and cities. However, it usually ranges from Rs 600 to Rs 1300 in India.
Price in Popular Diagnostic Centres
The table below lists the Anti-TPO antibodies test prices for major diagnostic centres in India.
| Diagnostic centers | Price |
|---|---|
| Thyrocare technologies | Rs 650 |
| Metropolis Healthcare | Rs 1300 |
| SRL Diagnostics | Rs 1200 |
| Aarthi Scans | Rs 750 |
| Dr Lal Path Labs | Rs 1300 |
| Vijaya Diagnostics | Rs 1100 |
City-wise prices
Prices tend to vary from one city to another. Usually, metro cities have higher prices, whereas tier 2 or tier 3 cities have lower prices. The table below lists the prices for major cities.
| City | Price |
|---|---|
| Anti TPO test cost in Delhi | Rs 600 to Rs 1300 |
| Anti TPO test cost in Gurgaon | Rs 600 to Rs 1425 |
| Anti TPO test cost in Hyderabad | Rs 595 to Rs 1400 |
| Anti TPO test cost in Chennai | Rs 595 to Rs 1300 |
| Anti TPO test cost in Mumbai | Rs 675 to Rs 1200 |
| Anti TPO test cost in Kolkata | Rs 585 to Rs 1200 |
| Anti TPO test cost in Bangalore | Rs 595 to Rs 1300 |
Thyroid disorders can be caused by multiple reasons and some other enzymes also. Thus, doctors often recommend Thyroid antibody tests, including anti-TPO and anti-TG (Thyroglobulin) tests.
Purpose of the Anti-TPO antibodies test
Anti TPO test is a specific method for measuring thyroid antibodies. It is beneficial in patients with elevated TSH, but Free T4 levels are normal. Some of the common symptoms when you may be asked for these tests are:
- Goitre (enlarged thyroid gland): It is marked by a swollen neck and is more common in malnourished children.
- Muscle weakness: This is a reduction in muscle tonicity.
- Gaining weight: This is a consequence of metabolic disturbances.
- Tiredness: This is marked by a lack of energy in the body.
There are the following purposes of the Anti-TPO antibodies test.
- To diagnose autoimmune disorders of the thyroid gland like Hashimoto’s disease or Graves’ disease.
- For confirmation whether the patient has autoimmune thyroid disorders or non-autoimmune goitre.
- Detect hypothyroidism (a medical condition involving less production of thyroxine hormone).
- Idiopathic myxedema is characterised as an atrophic (a shrunk or decreased size) thyroid gland and positive autoantibodies to the thyroid gland.
When is an Anti-TPO antibody test recommended?
A doctor recommends this test when other thyroid tests like TSH, Free T3, and T4 indicate thyroid gland disorder and enlargement. Other necessary thyroid tests which doctors may recommend are
- TSH receptor antibodies: TSH stands for Thyroid-stimulating hormone. This test involves the detection of antibodies that bind to the TSH receptors(Protein based binding vacant site).
- ATG (Anti Thyroglobulin antibodies): Thyroglobulin act as a material that produces thyroid hormones. Antithyroglobulin antibodies suggest thyroid gland damage due to the hyperactivity of the immune system. This test is helpful for autoimmune diseases like Graves disease and Systemic lupus erythematosus.
- FT3: This test measures Free triiodothyronine (T3) hormone levels in the blood. This hormone regulates muscularity, weight and body temperature.
- FT4: This is the free type of T4. The Free T4 penetrates the tissues when needed.
- T3: The T3 test measures triiodothyronine (T3) hormone levels in the bloodstream. This hormone regulates muscularity, weight and body temperature.
- T4: Thyroxine(alternatively known as T4) is a subtype of thyroid hormone. Excessive or insufficiency of T4 can indicate a thyroid disorder.
Preparation
- There are no special preparations necessary for a thyroid antibodies blood test.
- However, the patient must not eat dietary supplements containing biotin (vitamin B7). Vitamin B7 uptake is denied because it may increase thyroid function.
Procedure
The Anti-TPO test is a simple blood test that can be taken by your doctor or at a pathology lab. The steps of the procedure are as follows:
- The technician will rub the alcohol on the area of the skin. A syringe is taken.
- A needle is pricked into the blood veins.
- The blood is withdrawn with the help of a syringe.
- The technician will collect a blood sample into a test tube or vial.
- You may feel a slight sting when the needle goes in or out. The procedure usually takes less than five minutes.
Anti-TPO antibody test result
Test results indicate the level of anti-TPO antibodies present in the blood. If it is above the normal range, it may indicate thyroid dysfunction. Your physician co-relates the result with your condition and suggests a suitable measure.
Normal Range
The normal range for the test is less than 60 U/ml. You may note that the normal range depends on the test method and may vary from one diagnostic centre to another. Thus, it is crucial to look for the normal range in your report and take a repeat test for treatment follow-up from the same diagnostic centre. The table below lists the normal and high range for anti-TPO antibodies.
| Range | Unit | Remark |
|---|---|---|
| Less than 60 | U/ml | Normal |
| More than 60 | U/ml | High (Above normal) |
What do results mean?
Depending on your results, you may have a normal or high level of anti-TPO antibodies.
Normal Level
This signifies that antibodies are within acceptable limits. Your thyroid symptoms are probably not caused by an autoimmune disease.
High Level of Anti-TPO antibodies
It indicates a higher than acceptable level of antibodies to TPO and/or Tg (Thyroglobulin). This may mean you have an autoimmune thyroid disease. Increased levels are seen in patients with
- Hashimoto thyroiditis
- Graves disease
- Postpartum (after childbirth) thyroiditis
- Primary hypothyroidism due to Hashimoto thyroiditis
Some people with TPO antibodies may not have thyroid disease. But their presence may increase the risk of future thyroid disorders.
Usually, autoimmune diseases require medical intervention, and you should consult your doctor.
Sample Report
Risks
There is minimal risk of having a blood test. You may have slight pain or bruise when the needle is inserted, but most symptoms go away quickly.
₹999 ₹1100
Anti TPO Test
Frequently Asked Questions
Yes. Moderately increased thyroid peroxidase (TPO) antibodies may be found in patients with non-thyroid autoimmune diseases such as pernicious anaemia, type I diabetes, or other disorders that activate the immune system.
Thyroid disease can worsen during pregnancy. It can harm the mother and unborn baby. A pregnant thyroid disease patient may be tested for thyroid antibodies and tests involving thyroid hormone measurement.
The three types of thyroid antibodies are anti-thyroid peroxidase (TPOAb), anti-thyroglobulin antibody (TgAb), and TSH receptor antibodies (TrAb).
References:
- https://www.mayoclinic.org/thyroid-disease/expert-answers/faq-20058114#:~:text=TPO%20plays%20an%20important%20role,to%20help%20find%20the%20cause.
- https://medlineplus.gov/lab-tests/thyroid-antibodies/
- https://www.mayocliniclabs.com/test-catalog/Overview/81765#Clinical-and-Interpretive
Dr Bhumika Rana
Dr Bhumika Rana is a Bachelor of Ayurvedic Medicine & Surgery (B.A.M.S.). Earlier She was an Operation Specialist at AIIMS Delhi & a Medical officer with the National health mission.